Germline mutations in the NF2 gene is the cause of the Neurofibromatosis type 2, a tumour-prone disorder characterized by the development of multiple schwannomas and meningiomas, but importantly, NF2 is also frequently inactivated in human malignant pleural mesothelioma, a disease where YAP is frequently activated [33]. The gene discussed is NF2; the disease is NF2-related schwannomatosis.