In another investigation the same group found a 4-h incubation of tumor necrosis factor α-stimulated human umbilical vein endothelial cells with celecoxib to decrease ICAM-1 and vascular cell adhesion molecule 1 expression with a maximal inhibition of about 60% and 50% at 10 μM celecoxib, respectively, followed by reduced adhesion of colon cancer cells to endothelial cells [45]. The gene discussed is VCAM1; the disease is colonic neoplasm.