STAT3 and cancer: ADT causes cancer regression, because without androgen the rate of cell proliferation is lower and the rate of apoptosis increased, leading to extinction of these cells.19 We conclude that DAB2IP can modulate STAT3 activation and reprograms its target gene expression (i.e., survivin, Bcl-2 and Bax), which will shift the balance from pro-apoptotic to anti-apoptotic activities under androgen-depleted condition.