Furthermore, the interaction of the unique PR domain of DAB2IP with STAT3 may have a critical role, because our previous observation has shown that the PR domain in DAB2IP functions as a new inhibitory class of PR domain in modulating PI3K-Akt and Src-AR activity.11, 15 Taken together, these data provide supporting evidence that DAB2IP loss facilitates PCa cell survival after ADT through activating STAT3. Here, STAT3 is linked to posterior cortical atrophy.