It is consistent with previous studies that survivin mediates resistance to ADT in PCa,17 whereas Bcl-2 expression is augmented following ADT and is correlated with androgen-independent progression of PCa.23 In addition, Min et al.9 have also reported similar results that showed DAB2IP knocking down PrEC cells expressed higher levels of IL-6, VEGF, Bcl-2, Bcl-xL, C-IAP1, C-IAP2 and Myc genes, while DAB2IP-overexpressing PC-3 cells expressed lower levels of IL-6, C-IAP1, C-IAP2 and Myc genes, and all these genes were consistent with the activation status of STAT3. This evidence concerns the gene BIRC5 and posterior cortical atrophy.