Blocking the apoptosis signal would be one such pathway for tumor cell survival.17, 23 Indeed, our previous study has shown that DAB2IP can modulate AR activities and PCa cell growth.11 In addition to AR inhibition, this study further demonstrates that DAB2IP can modulate androgen-independent pathway that is involved in PCa cell survival after ADT. This evidence concerns the gene DAB2IP and posterior cortical atrophy.