HTRA2 and posterior cortical atrophy: Among various pro-apoptotic events, the disruption of ΔΨm and release of cytochrome c from the mitochondria to the cytoplasm are considered critical in mitochondria-mediated intrinsic apoptosis pathways.20 In this study we showed a dissipation of ΔΨm in DAB2IP-overexpressing PCa cells as evidenced by JC-1 staining, which was accompanied by the release of cytochrome c, Omi/HtrA2 and Smac from the mitochondria to the cytoplasm and further activation of downstream effectors Caspase-9, Caspase-3 and PARP.