In addition, NCBI GEO database (GSE4084) containing the gene profiles of human patient-derived xenografts (PDXs) collected from male mice up to 14 days after castration also showed a significantly increased expression of survivin but decreased expression of DAB2IP in the castrated mice (Figure 6b, left and middle panel); indeed, there is an inverse correlation between DAB2IP and survivin expression in these mouse xenografts or other human PCa tissues (GSE17951) (Figure 6b (right panel) and Figure 6c). This evidence concerns the gene BIRC5 and posterior cortical atrophy.