TTC, or the ‘broken heart syndrome', is characterized by transient and reversible myocardial stunning leading to systolic LV apical ballooning, is more prevalent in post-menopausal women and is triggered by emotional or physical stress by excessive epi release.1, 2 In our proposed mechanism, epi increases BAG3 protein levels through direct miR-371a-5p binding to the 3′-UTR region of BAG3 as demonstrated by the dual-luciferase assay. The gene discussed is BAG3; the disease is Tako-tsubo cardiomyopathy.