PKM and cancer: As indicated in Figure 6E, the expression of AKT2, AKT3, PKM2 and HK2 were significantly lower in the miR-29b agomir group compared with the NC agomir group, suggesting that miR-29b agomir treatment down-regulated in vivo AKT2/3 levels and further inhibited cancer cell glycolysis via downregulation of PKM2 and HK2 expression.