Nonetheless, just as infancy thymus provides superior cellular and humoral microenvironment as incubator of renewable T-cell subsets, so once retrogressive thymus microenvironment of tumor patients is equipped with special molecule re-expression, unique T-cell subsets may be reprogrammed for addressing in vivo resistant CSCs via evoking MHC-unrestricted immunocompetence renewal [8]. This evidence concerns the gene HLA-C and neoplasm.