However, in an independent experiment that tested whether there were differences in grown rates between shE2F3; GFP and shE2F3; GFP-Nek2, the overall tumor growth rate between shE2F3; GFP and shE2F3; GFP-Nek2 was statistically significant due to larger tumor volumes in the shE2F3; GFP-Nek2 mice between days 1 and 10 and no differences were found at later time points (Figure 1B, Table 1). Here, NEK2 is linked to neoplasm.