Although the role of CA and CIN as initiators of breast tumor formation remains to be tested experimentally, their presence in poor prognosis breast tumors, including Her2+ and Her2−ER−PR− (triple-negative), correlates with their aggressive behavior, marked by increased proliferation indexes, high nuclear grades, invasion, metastasis and poor survival [32, 35, 36, 38–42]. The gene discussed is ERBB2; the disease is breast neoplasm.