However, Nek2 kinase has other functions that may contribute to tumor growth, including phosphorylation of splicing factors that affect gene expression and cell cycle progression; in fact, knockdown of Nek2 or SRSF1 induces expression of pro-apoptotic variants from SRSF1-target genes and sensitizes cells to apoptosis [70]. The gene discussed is SRSF1; the disease is neoplasm.