Another nsSNP coding for the R1467H (Arg1467His), a C-terminal variant of PDZ-RhoGEF was found in association with insulin resistance and type II diabetes in several populations, including Pima Indians, Old Order Amish, Caucasian, Korean and Chinese (Bottcher et al., 2008; Fu et al., 2007; Jin et al., 2010; Liu et al., 2011; Ma et al., 2007). This evidence concerns the gene ARHGEF11 and type 2 diabetes mellitus.