Importantly, wild type but not PDZ-RhoGEF KO mice, developed glucose intolerance (Figure 6B, Figure 6—figure supplement 4A) and insulin resistance (Figure 6C, Figure 6—figure supplement 4B), as well as impaired insulin-dependent glucose transport in the soleus and EDL (Figure 6D). The gene discussed is ARHGEF11; the disease is Insulin resistance.