Further work on determining the nature of the PDZ-RhoGEF H1467R SNP variant, using functional reconstitution of PDZ-RhoGEF KO cells and mice, as well as biochemical characterization of its activity towards RhoA will be needed to fully understand its action in obesity and T2D predisposition. This evidence concerns the gene RHOA and obesity due to melanocortin 4 receptor deficiency.