This rationale was tested in a Phase III trial in NSCLC patients, wherein the combination of bevacizumab, an anti-VEGF monoclonal antibody, and the reversible EGFR tyrosine kinase inhibitor (TKI) erlotinib was compared with erlotinib monotherapy (Herbst et al, 2011). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.