Treatment with fatostatin induced the activation of mitochondrial-related caspase-9, and -3 and the cleavage of PARP but not caspase-8 (data not shown) in PC-3 R248W and DU145 cells, which reveal that fatostatin induces programmed cell death in PCa cells harboring mutant p53s mainly via an intrinsic mitochondrial-dependent apoptotic pathway. This evidence concerns the gene CASP9 and posterior cortical atrophy.