-Attenuating diabetes-associated hyperfiltration and tubular hypertrophy (Thomas)-Reducing the tubular toxicity of glucose- Reducing single-nephron glomerular filtration rate- In experimental diabetes reduce albuminuria and markers of renal inflammation- In animal models SGLT2 inhibits inflammatory response in kidney (TGF-β, MCP-1), and ↓apoptosis rates- Restoring tubuloglomerular feedback [92,93,98]. Here, SLC5A2 is linked to diabetes mellitus.