The result of clinical samples of HSA suggests that miR-214 and miR-126 are potential biomarkers for HSA; furthermore, given their extracellular functions, the over-secretion of miR-214 and miR-126 may function to accelerate the uncontrolled proliferation of neoplastic and tumor-associated ECs in a paracrine manner. The gene discussed is ALB; the disease is neoplasm.