ESR1 and breast neoplasm: The top interacting genes with PCBs as a chemical class were CYP1A1, AHR, CYP1A2, AR, CYP1A, CYP1B1, VCAM1, MAPK1, MAPK3, and PTGS2. The top interacting genes with PCBs in breast neoplasms were AR, CYP1A1, CYP1B1, ESR1, ESR2, PTGS2, and RAF1. Out of a total 200 genes interactions observed with individual PCBs, the interaction of genes AR, BAX, CYP1A1, CYP1B1, KDR, PARP1, PTGS2, and RAF1 was common with tetrachloride, pentachloride, and hexachloride biphenyls in beast neoplasms (Table 2).