Decreased liver fat content, liver weight, liver oxidative products, and prevention of fatty liver. Inhibition of mRNA and protein expression and diacylglycerol acyltransferase (DGAT) activity. No effects on mRNA expression of sterol regulatory element binding protein 1c (SREBP-1c), acetylCoA carboxylase 1 (ACC-1), fatty acid synthase (FAS), and carnitinepalmitoil transferase 1 (CPT-1). Here, SREBF1 is linked to fatty liver disease.