PPARA and metabolic dysfunction-associated steatotic liver disease: The final conclusion of the literature search by Valenti et al. [111] is that ACNs can prevent the progression of liver damage related to NAFLD by three independent mechanisms, namely, inhibition of lipogenesis by decrease of SREBP-1c, lipolysis promotion by induction of PPAR-α activity, and reduction of oxidative stress, pointing to foods rich in ACNs as a promising strategy for preventing NAFLD and its complications, however future RCTs are needed to test their hepatoprotective efficacy in NAFLD [113].