RHOB and chronic kidney disease: M'Baya-Moutoula et al. identified that miR-223 induced osteoclastogenesis by affecting the expression of NFIA and RHOB and they demonstrated an approach that overexpresses miR-223 to selectively increase osteoclast-like activity in calcified vessels of chronic kidney disease-mineral and bone disorder (CKD-MBD) to alleviate vascular calcification [49].