As shown in Table 3 and Figure 2D, multivariate analysis showed that serum albumin ≤3.5 g/dL (P = 0.005), AFP >20 ng/mL (P = 0.012), tumor size >3 cm (P = 0.028), and treatment modalities (resection as reference, RFA, P = 0.109; TACE, and P = 0.035; and other therapies, P = 0.012) were the independent risk factors predicting poor prognoses in BCLC stage 0 or A1 patients. Here, AFP is linked to neoplasm.