A previous study has shown that albumin is responsible for more than 70% of total blood antioxidant properties.14 Oxidative stress plays an important role in the development of ARHI.3 Current evidence supports the view that the cumulative effect of oxidative stress could induce damage to mitochondrial DNA in the cochlea and that the decrease in mitochondrial function can result in apoptosis of the cochlear cells. This evidence concerns the gene ALB and presbycusis.