For instance, B-cell eCGIs are enriched for regions binding key TFs involved in B-lymphopoiesis and lymphoma pathogenesis (such as BCL11A, EBF1, IKZF1 and SPI1), whereas ESC-specific eCGIs are enriched for binding of NANOG, a key TF regulating pluripotency (43,44). The gene discussed is EBF1; the disease is lymphoma.