MAPK3 and migraine disorder: The inflammatory model has been utilized in several studies and show similar findings to migraine for example TG activation with an increase in p-ERK1/2 activation and IL-1β expression, hypersensitivity to mechanical and thermal stimulation, as well as activation in the TG and in the brain stem trigeminal neurons, similar to what could be expected in migraine [17, 24, 29, 36, 37].