LEP and Insulin resistance: The results shown in Table 6 confirm the efficacy of 2-months well-balance intervention diet on metabolic changes: we observed a significant increase of glucagon like peptide-1 (p = 0.000) and a significant decrease of insulin resistance, assessed by HOMA (p = 0.006), leptin (p = 0.006), adiponectin (p = 0.0001), grelin (p =0.03), C-reactive protein (p = 0.004), ABSI (p = 0.000), BMI (p = 0.000) and android fat mass by DXA (p = 0.000).