MAVS and viral infectious disease: These factors include poly(rC)-binding protein 2, Gemin3 (RNA helicase that is a component of the SMN complex), RIG-I (retinoic acid-inducible gene 1; a cytoplasmic RNA helicase that senses viral infection), MAVS (mitochondrial antiviral-signaling protein), TRIF (Toll/interleukin (IL)-1 receptor domain-containing adaptor inducing IFN-β or innate immune adaptor molecules), and the stress granules protein G3BP [58–62].