SENP3 and cancer: SENP3, as a nucleolar protein, preferentially, nevertheless not exclusively, interacts with nuclear proteins (Drag and Salvesen, 2008; Gong and Yeh, 2006; Han et al., 2010; Hickey et al., 2012; Huang et al., 2009; Mukhopadhyay and Dasso, 2007; Yan et al., 2010), and has increased levels in various cancer tissues (Han et al., 2010; Hickey et al., 2012).