The genes mostly implicated in the inheritance of adenomatous polyposis, a condition that leads to colorectal cancer, are adenomatous polyposis coli (APC) involved in FAP (OMIM #175100) and mutY Homolog (MUTYH) involved in MUTYH-associated polyposis (MAP) (OMIM#608456). The gene discussed is MUTYH; the disease is polyposis.