LRPPRC and neoplasm: In addition to its role in post-transcriptional handling of mitochondrial mRNAs, LRPPRC has distinct functions in diverse cellular process; increased expression of LRPPRC has been documented in various tumours, contributing to the apoptosis resistance of human cancer cells (Tian et al., 2012) and it has been identified as an inhibitor of autophagy and mitophagy via interaction with the mitophagy initiator Parkin (Zou et al., 2014).