TNFSF10 and cancer: Taking all our data together, we propose a working model as follows: the activation of DR5 normally favors formation of the DISC, resulting in induction of apoptosis or anoikis as well as other potential biological consequences; this will not only lead to direct killing of detached cancer cells (e.g., via anoikis or TRAIL/DR5-mediated immunosurveillance), but also restrict the formation of another complex, the metastasis and invasion signaling complex (MISC), eventually resulting in suppression of cancer cell invasion and metastasis.