Coincides with nuclear expression of c-Myc protein, whose expression can be upregulated by WNT/B-catenin signaling in ~1/3 of tumor cells [67]; cytoplasmic and/or nuclear staining of Beta-catenin associated in preclinical study and in primary osteosarcomas with lung metastasis [68]. The gene discussed is CTNNB1; the disease is osteosarcoma.