Although some cancer cells in the As2O3-treated xenografts remained to be SOX2 positive (GSCs), these SOX2 signal almost overlapped with the PML staining (Figure 5G, Supplementary Figure S2E), and the majority of SOX+ cells (GSCs) were also PML-positive (Figure 5H, Supplementary Figure S2F). The gene discussed is PML; the disease is cancer.