Accumulating dada showed HIC1 is epigenetically silenced in various types of common human cancers such as prostate cancers [7, 8], hepatocellular carcinoma [9, 10], pancreatic cancer [11], hyperparathyroid tumors [12], renal cell carcinoma [13], et al. HIC1 promoter methylation is associated with tumor aggressiveness and poor survival [14]. Here, HIC1 is linked to familial pancreatic carcinoma.