Injection of PEP or IL-2 as positive controls stimulated vasopermeation in the MDA-MB-435 bearing CAMs in a dose-dependent manner with a maximum activity at 0.1 nM (Fig. 3A, left panel; Supplementary Fig. 1), similar to that seen in non-tumor bearing CAMs (Fig. 2A). The gene discussed is IL2; the disease is neoplasm.