Increased interstitial fluid may be most evident in the loose areolar tissue around the eye in a recumbent patient, and may indicate transient alterations in vascular permeability [although there was no difference in Ang-2 levels), renal dysfunction with fluid retention (although was no difference in creatinine and rates of acute kidney injury (AKI)], or other reversible disturbances of capillary hydrostatic or oncotic pressures. The gene discussed is ANGPT2; the disease is Abnormal renal physiology.