In the present study of experiment mode, our major new findings are two-fold: first, cereal dietary fibers in general normalized the expressions of SREBP1 and PPAR as well as other accompanied disorders (e.g. obesity, inflammatory biomarkers) in HFC diet-induced liver lipotoxicity and dyslipidemia in C57BL/6J mice; second, when these effects were compared, oat fiber could alleviate liver lipotoxicity and lipid profiles more effectively than wheat bran fiber. The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.