To address the importance of POH1 in regulating the growth of liver cancer cells, we generated the SK-Hep1 cells with a Tet-On inducible shRNA cassette against POH1 (sh-POH1-Tet-on; Supplementary Fig. 6i).Compared with the control groups, mice with induced sh-POH1 expression in tumour cells displayed a significant inhibition of tumour growth (P<0.001, by analysis of variance (ANOVA) analysis) (Fig. 4d–f). Here, PSMD14 is linked to neoplasm.