Besides the clinical evidence that aberrant upregulation of E2F1 frequently occurs in various types of human cancer and correlates with malignant progression and poor survival prognosis2, 3, 4, the E2F1-driven onocgenic activity has been reinforced in different models based on E2F1 transgenic or knockout mice5, 6, 7, 8. Here, E2F1 is linked to cancer.