PSMD14 and neoplasm: In addition, the multiple hypothesis test (Holm–Sidak's multiple comparisons test) was performed and these results showed that the protein levels of POH1 in stage T3/T4 tumours were significantly higher than those in tumours at earlier stages (T1 versus T2, P=0.845; T1 versus T3–T4, P=0.047; T2 versus T3–T4, P=0.005) (Fig. 7d).