50, 51. The positive enrichment score obtained from the analyses with the nominal P value=0.0175, false discovery rate Q value=0.0175 and FWER P value=0.009 (Fig. 8c), is indicative of a high enrichment in the expression of E2F1 target gene signature in the tumour subset with high POH1 expression. This evidence concerns the gene PSMD14 and neoplasm.