In addition to the identification of CpG methylation related to the TGF-β pathway, we identified 25 known preeclampsia-associated genes with altered CpG methylation with seven displaying functional changes in gene expression including AGTRAP and Col4a2. AGTRAP plays a role in the angiotensin pathway and Col4a2 is associated with early onset preeclampsia [2,7]. Here, COL4A2 is linked to preeclampsia.