Expression of the epidermal differentiation complex (EDC) genes filaggrin and loricrin was reduced in AD (FC~33 and ~38 respectively) contrary to the S100A7 (FC~6), A8 (FC~28) and A9 (FC~21) genes that are known to take part in antimicrobial responses and the chemotaxis of T cells and neutrophils. The gene discussed is SEMA4D; the disease is Alzheimer disease.