Human IPEX patients with loss-of-function Foxp3 mutations and congenital Treg cell deficiency present with neonatal diabetes, thyroiditis, autoimmune anemia and neutropenia, autoimmune hepatitis, exudative dermatitis, enteropathies, and hyper-IgE syndrome (Bennett et al., 2001; Torgerson and Ochs, 2007; Verbsky and Chatila, 2013). This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.