This metabolic switch from oxidative phosphorylation to increased glycolysis (i.e., the Warburg effect) is a common characteristic of malignant tumors [16, 17] and regulated by transcription factors, such as hypoxia inducible factor-1α (HIF-1α), v-myc avian myelocytomatosis viral oncogene homolog (c-Myc), and tumor suppressor p53 (p53) [18–20]. This evidence concerns the gene TP53 and cancer.