Determination of these gene expression levels in the pituitary following 60 days of estrogen treatment in fetal alcohol exposed and control rats revealed that the levels of DNMT1 and DNMT3B, but not DNMT3A, were significantly increased in AF rats compared to AD and PF controls (Fig 5A, 5B and 5C). The gene discussed is DNMT1; the disease is atrial fibrillation.