Thus, our data support the notion that an increased in the frequency of CD14+CD169+ cells may be associated with the development and progression of CRC and is concomitant rise of both pro-tumor (M2-like, IL-10 producing) as well as anti-tumor (M1-like, IL-12 producing) monocytes and tumor infiltrating macrophages. This evidence concerns the gene SIGLEC1 and colorectal carcinoma.