Interestingly, we also detected significantly higher percentages of CD14+CD169+CD163+ or CD14+CD169+CD206+ macrophages in TIMs than in circulating monocytes of CRC patients (data not shown), suggesting that peripheral blood CD14+CD169+ monocytes may migrate into the lamina propria and became M2-like cells. Here, MRC1 is linked to colorectal carcinoma.