SIRT1 rs3758391 T allele showed nominally significant associations with depressive disorders (OR = 1.19, 95% CI of 1.01 to 1.40, p = 0.040, see Table 3), metabolic syndrome (OR = 0.88, 95% CI of 0.80 to 0.97, p = 0.01, see Table 3), insulin resistance index (beta = -0.26, 95% CI of -0.48 to -0.04, p = 0.019, empirical p = 0.02, see Table 3) and blood glucose (beta = -0.05, CI of -0.09 to -0.002, p = 0.04, empirical p = 0.04, Table 3). The gene discussed is SIRT1; the disease is depressive disorder.