IFIH1 and acquired idiopathic inflammatory myopathy: For example, anti-melanoma differentiation-associated gene 5 (anti-MDA-5) antibodies are characteristic of a distinctive clinical subgroup with interstitial lung disease, and anti-transcription intermediary factor 1 (anti-TIF1) antibodies are characteristic of a subgroup of IIM patients who are at a high risk of developing cancer [3–4].