UNC93B1 and herpes simplex encephalitis: The importance of Unc93b and its client TLRs in initiating immune responses to viral infections was underscored when it was discovered that children inheriting two autosomal recessive mutant alleles of Unc93b that produce a non-functional, truncated version of the protein developed Herpes Simplex Encephalitis (HSE), a rare but serious viral encephalopathy, after Herpes Simplex Virus-1 (HSV-1) infection [10].