Fig 5A shows that such incubation results in a statistically significant increase in miR-202-3p levels (p = 0.02) in treated HS-5 cells compared to untreated controls. Next, we focused on a known target of miR-202-3p, namely Sufu a regulator of the Gli-Hedgehog signalling pathway with an established role in the oncogenesis of CLL.[36] Our selection was based on interrogation of the miRWalk database for miRNA-target interactions.[37, 38] In fact, both Sufu mRNA transcript variants 1 and 2 contain miR-202 target sequences in their 3’ untranslated region (UTR) (Figure D in S1 File). The gene discussed is GLI1; the disease is B-cell chronic lymphocytic leukemia.