Earlier studies of microvesicles and exosomes have demonstrated that these vesicles transfer RNA and protein content to alter recipient cell behaviour.[10, 11, 15] In line with other studies,[24, 25] we demonstrate that CLL exosomes are taken up by stromal cells and localise to late endosomes in the recipient cells as evidenced by co-localisation with the specific marker Lamp-1. The gene discussed is LAMP1; the disease is B-cell chronic lymphocytic leukemia.