2012), TFEB‐mediated autophagy has been reported to protect against α‐synuclein‐induced dopaminergic neuronal loss (Decressac et al. 2013). The expression of lysosomal proteins such as LAMP2A and GCase are decreased in the brains of sporadic PD brains (Alvarez‐Erviti et al. 2010; Dehay et al. 2010; Gegg et al. 2012). These deficiencies very likely contribute to the impairment of the ALP and thus the protein aggregation and mitochondrial dysfunction associated with PD (Terman et al. 2010; Nixon 2013). The gene discussed is TFEB; the disease is Parkinson disease.