2009). Many lysosomal genes have coordinated lysosomal enhancement and regulation sites in their promoters and are activated by the basic‐loop‐helix‐loop family of transcription factors such as transcription factor EB (TFEB) and MITF (Sardiello et al. 2009; Settembre and Ballabio 2014). The activation of TFEB has been suggested as a treatment for PD, since increased expression of this transcription factor protects against α‐synuclein and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine mediated dopaminergic cell death (Dehay et al. 2010; Decressac et al. 2013). Here, TFEB is linked to Parkinson disease.