Fifteen of the target-interactors plus beta-catenin itself have either been shown to be regulated by beta-catenin in small-scale studies (the Wnt Homepage (http://web.stanford.edu/group/nusselab/cgi-bin/wnt/target_genes); Herbst et al., Table 1 [17] or were regulated by beta-catenin in at least two of three colon cancer cell lines examined in a recent genome-wide study [17]. This evidence concerns the gene CTNNB1 and malignant colon neoplasm.