CDKAL1 and type 2 diabetes mellitus: Besides, gene expression of integrins and their ligands was found to be upregulated in rheumatology arthritis [25]. CDKAL1 (CDK5 regulatory subunit associated protein 1-like 1) is a member of the methylthiotransferase family and GWASs have linked intronic SNPs of CDKAL1 with susceptibility to type 2 diabetes [26].