C3 and chronic kidney disease: Besides, except for analyzing the association of the SNPs with LN susceptibility, we detected the association between trans-eSNPs genotypes and severity and outcome of LN patients in further, including their onset age, proteinuria, estimated glomerular filtration rate (eGFR), serum creatinine level, C3 level, systemic lupus nephritis disease activity index (SLEDAI) scores, percentage of crescent, different histological classes, response to treatment, and development of end stage renal disease (ESRD).