Most recently, using the cTnTR141W transgenic mouse model of DCM, Lu et al. tested whether knockdown of CYP2E1, a cytochrome P450 enzyme that catalyzes the metabolism of toxic substrates, could inhibit oxidative stress and apoptosis of myocytes to prevent DCM development [10]. Here, CYP2E1 is linked to familial dilated cardiomyopathy.