Current treatment strategies aim to improve insulin resistance by weight loss and exercise, improving insulin sensitivity by the use of insulin-sensitizing agents (e.g., pioglitazone) and reducing oxidative stress by the use of antioxidants, such as vitamin E. Some Chinese medicines with hypolipidemic, antidiabetic, and antiobesity effects have been used by traditional Chinese medicine doctors for over a thousand years. The gene discussed is INS; the disease is Insulin resistance.