ANGPTL4 and Cachexia: The metabolic effects of ANGPTL-4 support the idea that this protein contributes to cancer cachexia development: fat-specific Angptl4 overexpression caused a 50% reduction in adipose tissue weight, partly by enhancing fatty acid oxidation and lipolysis [48]; the central administration of ANGPTL4 lowered food intake and body weight gain and enhanced energy expenditure [49].