The tumour cell in hypoxia also increases the expression of macrophage chemoattractants such as VEGF, endothelins, IL-8, and endothelial monocyte activating polypeptide II (EMAP II) which promoted an increase in monocytes infiltration and macrophages accumulation, especially in tumour avascular or perinecrotic regions [28]. This evidence concerns the gene CXCL8 and neoplasm.