LEP and neoplasm: The accumulation of HIF-1α promotes the induction of several gene targets, such as leptin and the leptin receptor in tumour cells [87, 88], insulin-like growth factor-binding protein-1, vascular endothelial growth factor A [89], angiopoietin-2, angiopoietin-like 4, plasminogen activator inhibitor-1, glucose transporter-1, hexokinase-2, and glyceraldehyde-3-phosphate dehydrogenase [90]; it also seems to interfere with the transcription of Cdc6 and C-Myc during the regulation of the cell cycle [91].