At younger ages, overexpression of mouse IGFBP‐2 increased gonadal fat mass (Rehfeldt et al., 2010), whereas overexpression of human IGFBP‐2 in mice blocked the development of age‐related obesity later in life (Wheatcroft et al., 2007). This evidence concerns the gene IGFBP2 and obesity due to melanocortin 4 receptor deficiency.