BSG and neoplasm: Zhong et al. [15] found that CD147 expression was correlated with higher incidence of lymph node metastasis and lower differentiation in stage T1 pulmonary adenocarcinoma; Zhao et al. [16] found that CD147 expression was correlated with tumor invasion and metastasis in triple-negative breast cancer; in human astrocytomas and meningiomas, overexpression of CD147 was found in high-grade tumors, and it was positively correlated with WHO grades [17].