In our study, it is significantly related with survival of CRC patients and can also serve as an independent prognostic factor in multivariate analysis; what’s more, MMP-11 was associated with lymph node metastasis and distant metastasis, and also with tumor’s TNM stage, which was similar with results in non-small cell lung cancer and breast cancer [32, 33]. The gene discussed is MMP11; the disease is metastatic malignant neoplasm in the lymph nodes.